We will provide, at your request, the billing information necessary to submit to your insurance for you to obtain partial reimbursement for covered charges. Office visits (including the new patient consultation and future follow-up visits) and diagnostic imaging (such as: Xrays, MRIs, or in-house musculoskeletal ultrasound testing) are frequently covered by insurance plans. Please check with your insurance company for specifics about your out of network benefits.
The actual Regenexx procedures are still emerging, cutting-edge technologies that are not covered by insurance at this time.
- Blood-derived injections (Regenexx-SCP, Regenexx-PL disc, Regenexx-DDD), which utilize platelets and growth factors to encourage healing and regeneration to the area(s) injected.
- Bone-marrow-derived stem cell injections (Regenexx-SD). These procedures could encompass one or multiple visits and may also include the procedures listed above.
For an explanation of the complete list of procedures, please see: http://www.regenexx.com/regenexx-procedures-family/
- The severity of your specific condition
- The healing capabilities of your own body
- Positive factors – Healthy diet, regular exercise, reduced stress levels, etc.)
- Negative factors – Tobacco use, chronic disease, certain medications, high stress levels, mechanical abnormalities, neurologic abnormalities, prior surgeries, history of cortisone injections, bone spurs, etc.)
*People with many negative risk factors may still get an excellent response. If you elect to proceed in finding out your candidacy for a Regenexx procedure, Your doctor will discuss your specific medical circumstances with you, so you have a better understanding of how these procedures could be of benefit to you.
For more information on procedure outcomes, please visit our Patient Outcomes page.
Your doctor may also recommend multiple injections to you. What is exciting about regenerative medicine is that the benefit of any single procedure usually builds off of a previous regenerative injection. In other words, the benefit from a first injection does not seem to “fade away” (as compared to cortisone injections); a second or third series of injections would build upon the improvement from the first one.
For advanced conditions such as severe arthritis, Regenexx treatments can be an effective treatment strategy but can not be considered to be a cure of the condition. Although it is likely that the area will become more stable along with improved health of the tissue resulting in decrease in pain and improvement in overall function, a maintenance strategy of periodic injections is often recommended (usually with blood platelets) of the area to provide a continuous signal of healing (rather than breakdown). This may be as often as every 6 months (for conditions such as severe hip arthritis) to every 1-2 years for other conditions.
We do. We have been collecting patient outcome data for quite some time and we regularly and openly publish the results with the public. To view this data, visit our Outcomes Page.
This is on a case-by-case basis and although we have before, it would be at the advice of the doctor to treat more than one area. One of the many things that set Regenexx procedures apart from all other stem cell therapy being offered is dosage; to ensure the best possible outcome the doctor takes many factors into consideration, including your stem cell count.
When we first began offering orthopedic stem cell therapy in 2005 as part of an IRB approved medical study, we were one of the few clinics in the world treating orthopedic problems with stem cells. When we began treating everyday patients in 2007, this was still the case. Now other clinics are beginning to offer basic cell therapies, most in plastic surgery and cosmetics, with a few clinics just starting to try orthopedic therapies. While we welcome the growth in cell based medicine, we also know that we’re world leaders in this area. As leaders, we set a higher standard for ourselves in all of the cell-based procedures we offer our patients.
We have 2 pages dedicated to explaining the substantial differences between Regenexx and other stem cell solutions:
No. PRP is concentrating platelets in the blood, not stem cell therapy. This is a more detailed discussion on the differences between PRP and stem cell therapy. In addition, while PRP is one component of the therapy, we use a very different “Super Platelet Mix’ which we believe helps to produce many more stem cells.
We do offer the Regenexx® Super Concentrated Platelet Rich Plasma Procedure, which is a platelet procedure that is quite different from the bloody PRP commonly available using bedside centrifuges. To see a patient infographic on these differences, see this link for general info on the Regenexx platelet procedure and this one for a comparison between our process and typical bedside PRP machines.
Our registry based research has shown that, for stem cell procedures, older age does not adversely impact outcome.
The same day procedure involves taking cells and then isolating those over one day.
The cultured procedure grows those cells to larger numbers over a period of a few weeks.
Call us to schedule a phone review of your images with one of our doctors or schedule an appointment with one of our approximately 30 Regenexx Network sites around the country.
We carefully hand pick only the doctors who have the base skills to perform these procedures, which means we turn most away. We then train our physicians with an intensive education program.
That depends on which procedure is performed.
For example, for knee arthritis, you can expect 3 days of significant down-time followed by a slow return to normal activities over 6 weeks. While you may be asked to wear a brace, very few of our procedures require crutches.
Many mechanisms have been put forth, including long-term blocking of cells that destroy the joint, rescue of cells that fix the joint, and replacing lost native stem cells that maintain the joint.
No, while we have seen MRI evidence of cartilage growth in mild and moderate arthritis, we generally don’t see it with severe arthritis.
Because the procedure protocol will vary from person to person and because each person will have a unique condition to be treated, the pricing of procedures can vary considerably from patient to patient. An evaluation will give you a better idea of condition, treatment and costs specific to your condition. The chart below provides a general idea of the procedures and where they fall in terms of cost and severity of conditions treated. Platelet procedures cost considerably less than stem cell procedures.
Typical Condition Severity
|$$$||Cultured Stem Cell Procedure (Cayman Islands Only)*|
|$$||Stem Cell Treatment Protocol (USA & Worldwide)|
|$||Platelet Rich Plasma & Platelet Lysate|
No, these procedures are too new to be covered yet. Don’t let someone fool you, PRP and stem cell injections have no insurance coverage at this time.
Some health insurance plans may cover the initial evaluation. If your plan does, and we are part of your insurance carrier network, we will bill the carrier. If not, there will be a consultation fee for the initial face to face consult.
We recommend that you contact your insurance carrier for more information about your specific coverage details.
No, an analysis of the published research shows that liposuction is more risky than a bone marrow aspirate. More information on this can be found at the link below:
Approximately 10 years.
Using the HHS OHRP guidelines for complications reporting, our complications to date have been in the mild to moderate category and rare. This means that either the complication (like transient swelling) required no medical treatment (Mild), or if it did require medical treatment, the treatment was simple (Moderate-like a patient who failed the procedure who ultimately decided to get the knee replacement that he or she was planning before the procedure). We have published the world’s largest (to date) safety and complications tracking study of adult stem cell use in patients. This study did not show any serious stem cell related complications and it did not show that any patient developed a stem cell related cancer. In addition, our most recent safety paper was named the best of it’s type by a meta-analysis that appeared in the prestigious medical journal, Osteoarthritis and Cartilage.
The basic science on adult stem cells shows that if the cells are kept in culture for short periods, there is no risk of the cells becoming cancerous. We have published the world’s largest (to date) safety and complications tracking study of adult stem cell use in patients. This study did not show any serious stem cell related complications and it did not show that any patient developed a stem cell related cancer. Finally, we maintain an extensive complications tracking database with patient contacts at specified times. We have seen no evidence of significant complications at these re-implant sites. We also work with an outside lab for quality to clear each patient’s cells before they are used in treatment as an additional safety check.
No; they are exempt from FDA regulation.
Each of the Regenexx procedures available in the United States involves the patient’s own bone marrow or blood, and the Regenexx network of doctors only treat musculoskeletal conditions. Further, none of the Regenexx procedures available in the United States involves the culture expansion of the patient’s cells to create larger number of cells. Thus, the Regenexx procedures available in the United States generally fall into the following regulatory exemptions:
For our procedures involving concentrated bone marrow, minimally manipulated bone marrow for homologous use is not subject to FDA regulation as a human cell, tissue, or cellular or tissue-based product (HCT/P); 21 CFR 1271.3(d).
For our procedures involving autologous blood (such as PRP), practitioners who are licensed by law to prescribe or administer drugs and who manufacture blood products solely for use in the course of their professional practice are not subject to FDA regulation; 21 CFR 607.65.
Procedures involving the removal of an HCT/P from a patient and the implantation of that same HCT/P back into the same patient during the same surgical procedure are not subject to FDA regulation; 21 CFR 1271.15(b).
Regenexx is proud of its history of regulatory compliance and is deeply familiar with the regulatory environment in which it operates. If you have any questions about our regulatory compliance, please feel free to ask and we will be happy to speak with you in further detail.
Many patients ask why we need to draw blood and how much is taken. Blood is drawn from a vein in your arm and the amount drawn can vary significantly based on the type of procedure and your body weight, we also do a blood draw for the post-injection portion of our stem cell procedure protocol. The growth factors that we use to grow your stem cells and enhance your procedure are contained in your blood platelets. These same growth factors and blood platelets are used for our platelet rich plasma and platelet lysate procedures. More information on platelet procedures can be found here.
The cells are isolated in the lab using a proprietary separation technique. For the same day procedure, this isolated stem cell fraction is placed right back into the body. For more details on the stem cell procedure, click here.
All of our patients walk out of the clinic. However, having someone drive you for a medical procedure is never a bad idea. On occasion a local nerve block may be used, which could impair your ability to drive safely, so you should consult with your doctor or clinic about your specific treatment and protocol to ensure that it will be safe for you to drive if you wish to do so.
There is virtually no down time with this outpatient procedure. The entire process will take anywhere from 2-8 days depending on the doctor’s recommendation. You can walk right out of the clinic the same day any procedure is completed. For all blood-derived procedures (SCP, PL), you will only need to come in for one day for treatment.
We use real time x-ray known as fluoroscopy or musculoskeletal ultrasound. Your MRI images are used to help plan that injection.
About as painful as a typical shot in a doctor’s office.
Patients often confuse a bone marrow aspirate with a more involved and more painful bone marrow biopsy.
We only perform the less involved and much more comfortable bone marrow aspirate. This is a short (20 to 40 minute) in office procedure where the skin and tissues are numbed and a needle is used to withdraw marrow blood, which contains the stem cells. One site on each will be numbed and three samples are taken from each site. Because the area is extensively numbed, 88% of our patients report that the procedure is very comfortable and would do it again.
To better access how our patients feel about this procedure, we ran questionnaires on 44 consecutive patients undergoing marrow draws (primarily in Jan-Feb 2009). 86% said they had no to mild discomfort. 88% said that the procedure was either less uncomfortable or about what they thought it would be. 88% also said they would do it again without hesitation.
A properly performed marrow aspirate procedure should not be uncomfortable to the vast majority of patients.
Yes, we ask that all patients either use a home infra-red unit or another type of ultrasound unit to help with cell growth. The infra-red unit is available through Active Forever https://www.activeforever.com/
In general, we always try to look at more than one injured part. As a result, it’s very likely we will recommend other types of conservative care to restore normal biomechanics. This might include physical therapy, different types of myofascial release, or specific home exercises.
This depends on the type of procedure. However, all of our procedures are designed to promote as much early activity as possible. Here is a general guide: Bone healing procedure (for fracture non-union or avascular necrosis): You must be off the area on crutches until the pain from the procedure subsides. You can then move toward slowing increasing activities over the next few weeks. Total time off the area for most patients is 1-3 weeks with normal activities at about 6 weeks. The only exception is when there is an existing rod or plate stabilizing the fracture site, in these cases you will be allowed more activity more quickly. Joint procedure. If there is more minimal cartilage loss, low impact activities would be encouraged immediately after the procedure. Full high impact activities would be expected at 4-6 weeks. Partial tendon/ligament/muscle tear: Low impact activities would be encouraged immediately after the procedure. Full high impact activities would be expected at 4-6 weeks.
Yes, we have developed our own supplement based on lab tests with human mesenchymal stem cells and their response to various nutritional supplements. Click here for more info.
Some of our patients will require a second or even third procedure. Our usual protocol involves 1-3 injection cycles. Most patients get a single procedure.
The results should become apparent over 1-3 months, but sometimes can take as long as 6-9 months.