Concentrating on Concentration: PRP Dosage Matters

Like many things in life, dosage matters! Whether it’s making lemonade on a hot summer
day or brewing up a morning coffee, the concentration of your ingredients becomes an extremely
important factor for your recipe. For example, a traditional espresso shot has 64 mg of caffeine concentrated into a single fluid ounce of water, whereas a single fluid ounce of drip coffee only has 12 mg of caffeine in comparison. This means you would have to drink 5.3 times the amount of fluid of drip coffee to obtain the same concentration of caffeine that you would get from an espresso shot. This same
concept applies directly to PRP (platelet-rich plasma) treatments.
Some clinics offering PRP treatments for joint-related issues often utilize processing techniques where the highest concentration obtained is only 2 or 3 times. At Regenexx® at New Regeneration Orthopedics, through advanced and proprietary laboratory techniques, the platelet-rich plasma from your blood draw is concentrated at least 7 times, and upwards of 20 depending on age, joint size/type, and specific issue. This concentration is at our minimum double what other clinics can offer as their best, but why does this all matter?

Why does PRP Dosage Matter?

Through decades of clinical research in regenerative medicine, it was found that the responses of different-aged cells were measured in the environment of different concentrations of PRP. Patients’ cells under the age of 35 were found to respond at a maximal result to lower-dose PRP (7-10x concentrated), whereas those over 50 years old were found to require a higher dose (14-20x concentrated) to achieve the same maximal results. Our Regenexx® at New Regeneration Orthopedics Physicians utilize their many years of experience, expertise, and great results to tailor your PRP dosage needs based on your specific issue, body part, and demographics maximizing your results in a single procedure without the need to come back over several weeks.


If you have received a PRP procedure in the past elsewhere and feel underwhelmed or
disappointed by the results, the issue could have been the PRP dosage. Since we now know that
appropriate doses are needed to maximize responses, perhaps go back and ask your treating physician what the dosage of PRP was that you received, or if they aren’t able to tell you, how much of your blood was taken for the procedure. Then, with some simple math, you can see if the PRP dosage was on target for your age group’s maximized response concentration or if that clinic simply “missed the mark.”
At Regenexx® at New Regeneration Orthopedics of Florida, our physicians always tailor
the concentration and appropriate dosage of platelet-rich plasma for our patients. So whether it’s
the coffee you drink in the morning or the platelets in your plasma, concentration becomes the
secret ingredient for success. We are grateful to be servicing patients in the following areas of
Central and West Florida: Orlando, Tampa, St. Petersburg, and Sarasota.

  1. Berrigan WA, Bailowitz Z, Park A, Reddy A, Liu R, Lansdown D, A Higher ‘Platelet Dose May Yield Better Clinical Outcomes for PRP in the Treatment of Knee Osteoarthritis: A Systematic Review, Arthroscopy: The Journal of Arthroscopic and Related Surgery (2024), doi:

About The Author
Kyden Payne Medically Reviewed By Duron Lee, MD

Kyden Payne Medically Reviewed By Duron Lee, MD

Kyden Payne Medically Reviewed By Duron Lee, MD

Kyden Payne Medically Reviewed By Duron Lee, MD

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